Vince Ippolito Appointed as President and COO

  • Former Chief Commercial Officer at Anacor and Medicis joins leadership team
  • Mr. Ippolito has launched over 20 branded medicines in dermatology
  • Dermavant has licensed its fourth investigational drug for the treatment of acne

BASEL, Switzerland, September 29, 2017 /PRNewswire/ — Dermavant Sciences, a biopharmaceutical company focused on developing innovative therapies for dermatologic conditions, today announced the appointment of Vince Ippolito as President and Chief Operating Officer.

“I am extremely pleased to welcome Vince Ippolito to the Dermavant team,” said Dr. Jacqualyn A. Fouse, Executive Chair of Dermavant. “Vince brings a tremendous wealth of experience in dermatology. His track record speaks for itself and he has generated significant value for shareholders over the course of his highly successful career.”

"We now have four novel investigational drugs in our pipeline being developed by a highly experienced and dedicated clinical team,” continued Dr. Fouse. “Each compound has the potential to deliver significant value to patients with unmet medical needs in dermatology. It is a perfect time for Vince to join our team and help us take these programs forward.”

Mr. Ippolito has over thirty years of experience in the pharmaceutical industry, including twenty years in dermatology. He most recently served as the Chief Commercial Officer and Executive Vice President of Anacor Pharmaceuticals, a dermatology-focused biopharmaceutical company. At Anacor Mr. Ippolito was responsible for building marketing and sales functions, as well as developing the company’s product portfolio. Prior to Anacor, he was Executive Vice President at Medicis Pharmaceutical, an industry-leading dermatology company.

Over the course of his career, Mr. Ippolito has launched more than twenty brands in dermatology and he has played a leading role in two of the largest dermatology acquisitions of the past five years with combined valuations of $7.8 billion. Mr. Ippolito holds a B.A. in Business Administration, Management, and Operations from the University of Wisconsin with a minor in East Asian Studies from Sophia University in Japan.

"I am thrilled to be joining the Dermavant team and have been very impressed with their focus on bringing much-needed innovation to medical dermatology,” said Mr. Ippolito. “I am excited about the potential in Dermavant’s current pipeline and I look forward to advancing the current compounds in development while also building the pipeline further."

About Dermavant Sciences

Dermavant Sciences is dedicated to developing and, upon regulatory approval, commercializing innovative therapies in medical dermatology. Dermavant has four clinical-stage drugs in development: RVT-501, RVT-502, RVT-503, and RVT-201.

RVT-501 is a highly potent and selective topical phosphodiesterase-4 inhibitor currently in development for patients with mild-to-moderate atopic dermatitis. RVT-502, also known as cerdulatinib, is a dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor being developed as a topical therapy for a variety of serious dermatologic conditions. RVT-503 is an undisclosed preclinical asset being studied for the treatment of acne. RVT-201 is a caspase-1 inhibitor that acts to inhibit the production of inflammatory cytokines and is being developed for inflammatory skin diseases. For more information, please visit dermavant.com.

Appointment of Jackie Fouse

Dermavant Sciences Appoints Dr. Jacqualyn Fouse as Executive Chairman

  • Dr. Fouse recently served as President and COO of Celgene Corp. and a member of Celgene’s Board of Directors
  • Dr. Fouse joins growing network of industry leaders within the Roivant Sciences family of companies

BASEL, Switzerland, July 10, 2017 /PRNewswire/ -- Dermavant Sciences, a biopharmaceutical company dedicated to developing and commercializing innovative therapies in medical dermatology, today announced the appointment of Dr. Jacqualyn “Jackie” Fouse as Executive Chairman.

“I am honored to lead Dermavant and look forward to building the world’s leading innovative medical dermatology company,” said Dr. Fouse. “For the past decade there has been an 'innovation gap' in medical dermatology, with surprisingly few novel therapies despite a greater understanding of the pathophysiology of many dermatologic conditions. Physicians and patients are eager for better options.”

“In less than two years, Dermavant has created a robust pipeline of promising potential therapies targeting multiple indications,” Dr. Fouse continued. “I believe the company is well on its way to being the ideal development and commercialization partner for innovative dermatology medicines. I am impressed with the quality of the Dermavant team and the entire Roivant organization.”

“We are delighted to welcome Jackie to the helm of Dermavant,” said Vivek Ramaswamy, Founder and Chief Executive Officer of Roivant Sciences. “She is an exceptional leader and one of the most admired executives in the biopharmaceutical industry. Jackie is emblematic of the caliber of leadership that we seek to attract to the Roivant family of companies.”

Dr. Fouse previously served as President and Chief Operating Officer of Celgene Corporation until April 2017, and as a member of Celgene’s Board of Directors through June 2017. She joined Celgene in 2010 as Chief Financial Officer and was named president of the company’s global Hematology & Oncology franchise in 2014. Her experience at Celgene included working closely with the business unit that launched OTEZLA® for the treatment of moderate-to-severe plaque psoriasis and active psoriatic arthritis.

Before joining Celgene, Dr. Fouse served as Chief Financial Officer of Bunge Limited, a leading global agribusiness and food company. Prior to Bunge, she served as Senior Vice President, Chief Financial Officer, and Head of Corporate Strategy at Alcon Laboratories, a leading ophthalmic pharmaceutical and medical device company. Prior to her tenure with Alcon, she held a variety of senior leadership roles with international companies, spending almost a decade of her career in Switzerland. Dr. Fouse earned her B.A. and M.A. in Economics and a Ph.D. in Finance from the University of Texas at Arlington.

About Dermavant Sciences

Dermavant Sciences is dedicated to developing and, upon regulatory approval, commercializing innovative therapies in medical dermatology. Dermavant currently has three investigational drugs in development: RVT-501, RVT-502, and RVT-201. RVT-501 is a highly potent and selective topical phosphodiesterase-4 inhibitor currently in a Phase 2 clinical program for patients with mild-to-moderate atopic dermatitis. RVT-502, also known as cerdulatinib, is a dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor being developed as a topical therapy for a variety of serious dermatologic conditions. RVT-201 is a caspase-1 inhibitor that acts to inhibit the production of inflammatory cytokines and is being developed for inflammatory skin diseases. For more information, please contact us.

About Roivant Sciences

Roivant Sciences is dedicated to realizing the full potential of promising biomedical research by developing and commercializing novel therapies across diverse therapeutic areas. Roivant partners with innovative biopharmaceutical companies and academic institutions to ensure that important medicines are rapidly developed and delivered to patients. Roivant advances its drug pipelines through wholly- or majority-owned subsidiary companies, including Axovant (NYSE: AXON) (neurology), Myovant (NYSE: MYOV) (women’s health and endocrine diseases), Dermavant (dermatology), Enzyvant (rare diseases), and Urovant (urology). Roivant’s partners include Merck, Takeda Pharmaceuticals, GlaxoSmithKline, Eisai, Vertex Pharmaceuticals, Duke University, and Cincinnati Children’s Hospital Medical Center. Roivant’s long-range mission is to reduce the time and cost of developing new medicines for patients. For more information, please visit roivant.com

Licensing of Topical Cerdulatinib

Dermavant Sciences Announces Licensing of Topical Cerdulatinib from Portola Pharmaceuticals for Dermatologic Indications

– Cerdulatinib is a dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor – Dermavant plans to develop cerdulatinib as a topical therapy for a range of dermatologic conditions while Portola retains all systemic rights – Jim Lee, MD, PhD, named Chief Medical Officer of Dermavant

BASEL, Switzerland, Dec. 21, 2016 /PRNewswire/ — Dermavant Sciences, a biopharmaceutical company focused on developing innovative therapies for dermatologic conditions, today announced that it has entered into an exclusive worldwide licensing agreement with Portola Pharmaceuticals, Inc. for the development and commercialization of cerdulatinib in topical applications beyond oncology.

Cerdulatinib is a dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor that Portola is developing to treat patients with resistant or relapsed hematologic cancer. Cerdulatinib is currently being investigated in an ongoing Phase 2a trial in patients with relapsed/refractory B-cell malignancies who have failed multiple therapies. Under the terms of the agreement with Dermavant, Portola retains full rights to all non-topical formulations of cerdulatinib, including oral formulations.

Dermavant, a subsidiary of Roivant Sciences, intends to pursue the clinical development of cerdulatinib as a topical therapy for a variety of dermatologic conditions. Dermavant believes that the profile of cerdulatinib is ideal for development in these skin diseases where a growing body of evidence suggests that both JAK and Syk are important drivers of disease manifestation.

“The addition of cerdulatinib to our pipeline renders Dermavant an emerging leader in medical dermatology,” said Jim Lee, MD, PhD, the newly-appointed Chief Medical Officer of Dermavant. “Given the anti-inflammatory properties associated with both JAK and Syk inhibition we look forward to advancing the clinical development of cerdulatinib as a potential therapy for a number of dermatologic conditions with significant unmet need.”

Appointment of Dr. Jim Lee as Chief Medical Officer

Dermavant’s Chief Medical Officer, Dr. Jim Lee, brings over 17 years of experience in successfully developing multiple therapies across various indications in the field of dermatology. Most recently he served as Vice President, Global Head of Clinical Development at Stiefel Laboratories from 2011 to 2016. Dr. Lee previously served as Chief Medical Officer at Graceway Pharmaceuticals LLC and Director of Immunology at Centocor Inc. Dr. Lee received his MD and PhD in Biochemistry and Molecular Biology from the University of Illinois College of Medicine.

About Dermavant Sciences

Dermavant Sciences is a biopharmaceutical company focused on developing innovative therapies for dermatologic conditions. Dermavant is currently enrolling patients with mild-to-moderate atopic dermatitis in a Phase 2 clinical study for RVT-501, an investigational topical phosphodiesterase-4 inhibitor. Dermavant also plans to pursue the clinical development of RVT-201, a novel caspase-1 inhibitor, as a topical therapy for multiple dermatologic conditions.

Related Links

http://roivant.com/eczema/

Licensing of RVT-501

Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, “Eisai”) announced today that it has entered into an agreement to license its in-house discovered selective phosphodiesterase 4 (PDE4) inhibitor E6005 to Roivant Sciences Ltd. (Roivant).

Under the agreement, Eisai will grant Roivant an exclusive worldwide license (including Japan) concerning the research, development, manufacture and marketing of E6005. Currently, E6005 is at the Phase II clinical trial stage for atopic dermatitis in Japan, and Roivant will conduct research and development going forward. Furthermore, according to the agreement, Eisai will receive a one-time upfront payment from Roivant, and will also receive milestone payments in line with future development progress as well as specified royalty payments after market launch.

Discovered in-house by Eisai’s Tsukuba Research Institute, E6005 is a selective PDE4 inhibitor. It is known that PDE4 is an enzyme that degrades the second messenger cyclic AMP. PDE4 is involved in inflammation and the immune response. In non-clinical and clinical studies conducted to date by Eisai, E6005 exhibits anti-inflammatory effects and suggests suppression of itching relating to atopic dermatitis by selectively inhibiting PDE4. Furthermore, in clinical studies of the agent in adult and pediatric patients with atopic dermatitis, no serious safety concerns that could pose problems in a clinical setting were observed. As it is known that the interaction between itching and inflammation leads to worsening and the chronic state of atopic dermatitis, E6005 has the potential to become a new treatment option for atopic dermatitis with its demonstrated effect on reducing inflammation and suppressing itching as well as favorable safety profile.

Roivant is a pharmaceutical company with a unique business model of strategically acquiring businesses and pipeline products from other companies. Eisai positions oncology and neurology as its key therapeutic areas, and focuses investment of research and development resources accordingly. By licensing E6005, which will be known as RVT-501 going forward to Roivant, Eisai aims to maximize the value of the compound as well as accelerate its development in order to contribute to the treatment of patients with inflammatory/autoimmune diseases starting with atopic dermatitis as soon as possible.

About E6005 (Roivant development code: RVT-501)

E6005 (RVT-501) is a selective phosphodiesterase 4 inhibitor discovered in-house by Eisai. Distributed in many cells involved in inflammation and immune response, PDE4 is an enzyme that influences the transmission of inflammation signals by degrading the intracellular signaling molecule cyclic AMP. It is reported that exacerbation of PDE4 activity leads to increased production of inflammatory mediators, making the condition worse and chronic in nature, and at atopic dermatitis lesion sites, exacerbation of PDE4 activity can be observed. In non-clinical and clinical studies conducted by Eisai, E6005 exhibits anti-inflammatory effects and suggests suppression of itching relating to atopic dermatitis by selectively inhibiting PDE4. Currently, E6005 is at the Phase II stage of clinical trials as a transdermal PDE4 inhibitor for adults and pediatric patients with atopic dermatitis, and with its demonstrated effect on both reducing inflammation and suppressing itching as well as favorable safety profile, E6005 has the potential to become a new treatment option for atopic dermatitis.